Don’t you think the time has come to improve liver function assessment?
Patent: MICRO-RNA SIGNATURES FOR THE PREDICTION OF LIVER DYSFUNCTION
National patent number: 50804/2018
ABSTRACT
The invention relates to an in vitro method of determining a subject’s risk of liver dysfunction, specifically after partial liver resection, said method comprising the steps of providing a sample from said subject, determining in said sample the expression level of at least one miRNA, selected from the group consisting of 5 miR-151a, miR-192 and miR-122, and comparing these expression level(s) with at least one reference expression level, or identifying the ratios of the expression levels of miR-151a to miR- 192 and/or of miR-122 to miR-151a and comparing said expression level ratios with reference expression level ratios, and classifying the sample from the outcome of the 10 comparison into one of at least two classes, wherein each class is one of the at least two categories “high-risk” and “low-risk”.
We are currently developing an easy clinically applicable tool to allow preoperative risk assessment prior to liver surgery in daily routine